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A genetic Metformin, for diabetes could treat many other diseases

A herb, rich in galegine(Goat’s rue), from a herb to medicine, a genetic medicine, Metformin has been treated for type II diabetes and other ailments for thousands of years. A recent study says Metformin could help other age-related diseases such as heart disease, cancer, and cognitive decline. According to NPR, The research suggests metformin has anti-inflammatory effects that could help protect against these diseases.

Scientists of this study published through The TAME Trial (Targeting Aging with Metformin) is a series of nationwide, six-year clinical trials at 14 leading research institutions across the country that have engaged over 3,000 people between the ages of 65-79. According to the Afar.org., Wake Forest University School of Medicine took a megaphone to research aging-related diseases by taking metformin to prevent or reduce the diseases.

This research is still ongoing but taking metformin has more pros than cons. Of course, there are side effects too. However, the scientific research results of a few million metformin users have flavonoid effects while taking the medicine.

A herbal ingredient of galegine, hydroxygalegine, and several guanidine derivatives, such as 4-hydroxygalegine flavones, flavone glycosides, kaempferol(used for fat loss and cancer), and quercetin(reduce allergic responses of boost immunity). According to the NIH, Flavonoids possess several medicinal benefits, including anticancer, antioxidant, anti-inflammatory, and antiviral properties. They also have neuroprotective and cardio-protective effects.

Its usage has been from medieval Europe to treat bubonic plague, worms, and snake bites as traditional medicine. It has been used in two different types of medicine as anti-diabetic drugs: phenformin, and buformin in the 20th century.

21st century, metformin researchers found it lowers blood glucose levels, increases insulin sensitivity and weight control, and induces diuresis. Recent research suggests that it might be helpful for heart disease, cancer, and dementia by taking metformin.

Side effects may cause headaches, muscular weakness, diarrhea, iron absorption, and anticoagulants (blood thinner). While in pregnancy or breastfeeding needed to avoid metformin. According to Drugs.com in 2017.

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